Day 4 (Friday, Nov 5)
Was under the weather, so missed the first morning session. Need to check out the cancer genomic session abstracts and info. I wandered around the vendors until lunch, and had some nice discussions with various people. I especially focused on analysis and annotation of coding variation from NGS data.
In the first afternoon session, I chose to sit in on the pop gen session. I found one talk on synonymous SNPs interesting. The talk suggested that, as suggested in recent literature, synonymous SNPs are not always "silent", and that the differences can be explained by selection on translation efficiency. The question I have is how often this really has an effect on disease phenotype. It has been shown to be relevant for at least a few diseases, but...
Thought: dN/dS ratio is commonly used to measure evolutionary conservation of a region. Can this be used in a similar way to the ts/tv ratio for evaluating SNP discovery?
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